CTCAE Bookmarks


The National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) is a standardized system to quantify or grade the severity of adverse events (AE) that occur with drug treatment or from medical devices. A definition of mild (grade 1), moderate (2), severe (3) and life-threatening (4) events is provided for each AE term.

The Department of Biomedical and Health Informatics (DBHi) at The Children’s Hospital of Philadelphia has converted the 260+ pages of both CTCAE documents into intuitive iPhone applications. With these applications, healthcare providers can reference the full CTCAE v3.0 and v4.0 with an iPhone or iPod Touch, allowing for bedside grading at the time of a visit and generally allowing the information to be accessed from anywhere at any time.

Two versions of the CTCAE are widely used and are supported by separate CBMi-developed mobile health applications:

  • CTCAEv4.0 was published by NCI on May 28, 2009 and is increasingly used by many healthcare providers and researchers to characterize adverse events consistently.


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